Consumption of alcohol and marijuana at the same time can induce a state of intense "sickness". Someone likes that alcohol causes him enriched noise, but then drinks less of it; and someone, in turn, enjoys both states to the fullest. However, most people do not recommend mixing these two substances because they have experienced unpleasant conditions such as nausea, dizziness and other insurmountable feelings that this combination can cause.
But subjective preferences aside, what does research say?
Alcohol acts on the human brain by suppressing the secretion of the excitatory neurotransmitter glutamic acid aka glutamate and, conversely, promotes the secretion of the suppressive neurotransmitter gamma-aminobutyric acid (GABA). A neurotransmitter is a chemical that allows neurons to communicate with each other and transmit excitement. In the end, it seems that a drunk person is less receptive, slower to understand, and remembers a few.
The grass in the brain acts with its active ingredient THC - tetrahydrocannabinol, which fits into cannabinoid receptors, after which the neurons together generate a massive fantasy and confusion of thoughts. However, marijuana has in common with the suppression of glutamate secretion. Glutamate is an essential substance in learning. Rats intoxicated with alcohol and marijuana remembered much less than rats that were either stunned or drunk.
Furthermore, drinking has been found to enhance noise. Alcohol dilates blood vessels (acts as a vasodilator), after which more THC enters the bloodstream. This is confirmed by a study in which participants, after two doses of alcohol, had twice the THC values in their blood plasma after being overwhelmed, compared to those who received placebo instead of alcohol.
Marijuana also works against vomiting, which is useful, for example, in the treatment of chemotherapy. In drunkenness, on the other hand, it is detrimental, because the body prevents poisoning with vomiting.
In any case, each of us can react to these two substances (or a combination of them) differently. What is poison to one can be a cheerful diversification for the other. It is generally recommended to listen to your body's signals and preventive sobriety. 🙂